MSM (Methylsulfonylmethane) INFORMATION
For those who are curious about our "Silver Fortified Water with MSM", but are not familiar with the benefits of MSM itself, read the following studies and information carefully. As you read this, make a 'list' of the multitude of benefits of MSM. Next, combine these benefits with a 'list' of the known benefits of colloidal silver! Make note of the total lack of toxicity and side effects! Also, observe the 'synergism' - SFW 'with' MSM being even more effective than the 'combined results' of the two acting separately!. Our "field testing" has confirmed this.
For example: we know arthritis is caused by bacteria, and that silver is effective against these pathogens. We also know that MSM softens tissue, increases blood supply, reduces inflamation, and relieves the pain of arthritis. Put the two together! You will begin to see a picture forming - a picture of a "very powerful", all natural, product with vast potential. This is only 'one' of the numerous possibilities.
There is no "secret" to our product, other than 'quality'. Our only secret is in how we mix the two without degrading the stability and efficacy of either.
Here for your health.
Many years of clinical use at Oregon Health Sciences University has demonstrated that MSM provides the following pain relief and anti-inflammatory benefits without serious side effects:
MSM is often so effective for pain relief that doctors are able to lower the dosage of medication they prescribe for patients. Sometimes, they are even able to discontinue the medication altogether. The end result is relief along with fewer or no side effects that are frequently caused by prescriptive medications.
LIGNISUL MSM (Methylsulfonylmethane)
IN THE TREATMENT OF ACUTE ATHLETIC INJURIES
By Ronald M. Lawrence, M.D., Ph.D. Daniel Sanchez, D.C., C.C.S.P. Mark Grosman, D.C.
ABSTRACT: Twenty-four subjects (both male and female) were seen in a clinical office setting. The subjects suffered from acute injuries (under 30 days) sustained during the course of athletic endeavor. The patient's were selected on a random basis to receive either a placebo or Lignisul MSM (methylsulfonylmethane) in addition to routine chiropractic manipulation, ultrasound and muscle stimulation at each visit. All patients were treated with similar therapy and all patients received unmarked capsules of either a placebo or Lignisul MSM. Patients were discharged from care once all their symptoms were resolved. Of the twelve patients who received placebo four of the twelve graded their results as excellent or good, while of the twelve patients on Lignisul MSM seven of the twelve graded their symptom reduction as excellent or good. This represented a 58.3% of symptom reduction on Lignisul MSM, versus 33.3% on placebo. Of greater significance, however, was the fact that patients on Lignisul MSM had 3.25 visits on an average, while those on placebo had 5.25 visits. This means that patients on Lignisul MSM had 40% fewer visits to the office before reaching a recovery phase. This represents sizable economic advantage. This paper discusses the chemical nature of MSM, the possible mechanisms involved in treatment of such sports injuries and the implications for future usage of this phytonutrient for the treatment of short term athletic injuries.
INTRODUCTION: Methylsulfonylmethane (MSM) was first discovered in the late 1970's by researchers at Oregon Health Sciences University in Portland. It is a metabolite of DMSO (Dimethyl sulfoxide). By 1965, more than one thousand five hundred studies had been conducted on DMSO involving about one hundred thousand patients. DMSO is used for a host of problems, primarily musculoskeletal inflammatory conditions. However, by 1978, the FDA approved DMSO only as a prescriptive treatment for interstitial cystitis. When DMSO enters the body, approximately 15% of it is converted to MSM, its major breakdown component. MSM is in reality DMS0 2 (dimethyl sulfone). MSM has had widespread use since the late 1970's in veterinary medicine where it has been used to treat inflammatory conditions, including muscle and bone disorders. (1, 2, 3, 4, 5) In 1998, one of the authors of this paper, Ronald M. Lawrence, performed a double- blind study using patients with degenerative arthritis. This study showed an 82% decrease in symptomatology after six weeks of usage on a three-times-a-day dosage. (6) It has been postulated that MSM takes anywhere from three to six weeks to produce significant changes in regard to the treatment of arthritic disorders, but to date there has been no study that has evaluated it for acute short-term injuries. R. D. Moore and J. I. Morton studied the effect of MSM in inflammatory joint disease in MRL/1pr mice. (7) In addition, R.D. Moore and Morton studied the effect of 3% water solutions of dimethyl sulfone (DMSO 2) in P1w mice and found a diminishment in death due to lupus nephritis.(9) B. V. Siegel and J. Morton studied the effects of dimethyl sulfone on murine autoimmune lymphoproliferative disease and explained the benefits of this compound. (9) Since one-third of the DMSO 2 molecule is composed of sulfur, a relationship to sulfur metabolism has been postulated. Several papers have been written about sulfur and it's roles in such disorders of the musculoskeletal type. (10,11) For this reason, and because of the effective results noted in the treatment of degenerative arthritis, this study was undertaken to evaluate the potential effects of DMSO 2 (MSM) in athletic injuries involving muscles, tendons, and ligaments.
METHODS Twenty-four subjects were examined in a clinical practice setting (the practice of Daniel Sanchez and Mark Grosman). This practice deals with a large number of athletic injuries on a daily basis. The first twenty-four subjects who came in with complaints of acute injury were admitted into the study and the subjects were divided in a random fashion into two groups (A and B). The twelve subjects in group A received a container labeled "A" which had a thirty-day supply of capsules, while the twelve in group B received a contained labeled "B". The doctors and patients involved were not privy as to whether they received placebo or actual Lignisul MSM. The code, which defined whether bottle A or bottle B contained placebo or active substance, was no broken until after the completion of the study. Nine of the twelve patients taking bottle A had diagnoses of sprain/strain injuries, one had an acute episode of bilateral chondromalacia patellae, one patient had a right lateral epicondylitis (right elbow), and one patient had a radicular syndrome (bilaterally) in addition to a lumbar strain syndrome. In the group taking bottle B, ten subjects had a sprain/strain diagnoses, while one subject had a radiculopathy involving the left lower extremity along with a lumbar sprain syndrome and one patient exhibited a lateral epicondylitis involving the right elbow. Each patient received chiropractic manipulation in a standard fashion, ultrasound (five watts for ten minutes) and muscle stimulation (applied in a standard fashion for five minutes). Each subject took the material in either bottle A of bottle B three times a day with meals. The only differential between treatment given to each group was the administration of either the placebo or the phytonutrient Lignisul MSM. All patients were examined in a similar fashion for angle of motion of the part or parts involved and this was duly recorded. Patients were also quizzed as to subjective complaints at the time of each visit. In addition, palpatory findings in regard to the musculature in the involved area was recorded on the basis of zero to four plus, with zero being the absence of any type of muscle spasm beyond that of a normal resting state, while four-plus represented extreme muscle spasm based on the rigidity of the muscle involved. This information was recorded at each visit as well. In those injuries involving the upper extremities a Jamar Hand Dynamometer evaluation of grip strength was recorded at each visit. In those exhibiting lower extremity or low back injuries, straight-leg raising testing was performed at each visit and the degrees of elevation from the horizontal were noted and recorded.
RESULTS: Those patients in the aliquot which consumed the Lignisul MSM, on average, reported a faster reduction of symptomatology than those on the placebo. Four of the subjects taking the MSM reported the "Disappearance" of symptoms after taking the capsules for a very short period of time. (We shall discuss this below). Symptom resolution and evaluation also consisted of the objective findings noted by the examining doctors at each visit. Response of the patients in regard to their symptoms were graded on a scale of zero to ten with ten being the severest pain and zero representing an absence of pain. This evaluation of the symptom level of pain was performed at each of the visits. Therefore the patients were evaluated objectively by the doctor at each visit and there was a subjective evaluation in regard to the patient's own perception level of pain. Since we were dealing with very small study groups the excellent and good categories were combined in arithmetic fashion and the satisfactory category and poor category were grouped together, again for purposes of statistical evaluation in using this small group of subjects. Seven out of twelve in the A category showed excellent to good results (58.3%). Those in the B category showed four out of twelve having excellent to good results (33.3%). In the satisfactory to poor categories, the total for the A group was five of twelve (41.66%) versus eight of twelve in the B category (66.66%). Since economic considerations are very important, we determined the number of visits for each group. The number of visits, on average, for group A was 3.25 versus group B which was 5.25 visits. This represents a 40% reduction in visits. The economic advantages of reduced number of office visits was clearly noted with patients on Lignisul MSM. This is also reflected in reduced disability time. One patient in group A (who had an acute flare-up of bilateral chondromalacia patellae) noted complete resolution of her pain within two visits. Past episodes of this problem had usually taken up to four visits to resolve and up to two weeks to clear. This patient had resolution of her problem in less than one week. One patient who had a diagnosis of left ankle sprain/strain of a severe type noted a complete resolution of her problems within three visits over a period of one week, with a reduction of plus-four swelling of the ankle joint, resolving within two days after beginning the test substance ("A"). One patient in group A with a diagnosis of moderate cervical strain with associated radical syndrome of the right upper extremity noted complete relief of her discomfort within one week. Another patient with an episodic flare-up of lumbar radicular syndrome involving the left lower extremity noted a 70% improvement in five days (category A) where typical flare-ups in the past required approximately ten to fourteen days to resolve. One patient with left elbow medial collateral ligament sprain (grade I) needed only two visits and five days of taking bottle A to resolve her symptomatology. One patient with a lumbar strain diagnosis eventually was diagnosed with a herniated nucleus pulposus (ruptured disc) and substance A did not produce a resolution of his symptomatology within thirty days. A male, age sixteen, who fell while playing softball and injured his right elbow (diagnosed with right elbow strain, medial collateral ligament grade I strain) noted a disappearance of symptoms within two days and the examining doctor found full range of motion (which had been impaired by 25%) after two days on bottle A. One patient with lumbar sprain syndrome and associated pyriformis syndrome went from severe to slight within two days after starting bottle A.
CONCLUSIONS AND DISCUSSION: In this small study using Lignisul MSM versus a placebo (both administered in a similar capsule form and both capsules appearing exactly the same to the examiners and the patients) it was discovered that those taking substance Lignisul MSM had a level of significant recovery from short-term injuries or flare-ups of previously induced athletic injuries. From the economic point of view, we were particularly gratified to see a marked reduction (40%) in the number of visits usually required to treat these injuries. It is postulated that MSM has an anti-inflammatory action based upon increased blood flow to the injured part (dilation of blood vessels and enhanced blood supply), reduction in muscle spasm and change in cellular membrane potentials involving sodium-potassium transfer. (12) Since MSM, a phytonutrient, has been shown to have a very low level of toxicity (comparable to water) and since the substance has also been widely used in veterinary medicine without showing any toxic results as well, the use of Lignisul MSM to treat human sprains, strains and athletic injuries appears to be very beneficial based on this small but intensive study. A larger study involving several hundred subjects is being planned and these subjects will be taken from a sports medicine practice. It is felt by the authors that Lignisul MSM, in view of it's low toxicity, inexpensive costs, and ease of administration, should be considered as an invaluable addition for treatment of short-term athletic injuries of the type that were involved in this study. It was previously shown in a double blind study that Lignisul MSM had a high rate of effectively in a chronic painful condition involving osteoarthritis, the physiologic actions of MSM are apparently similar in producing an alleviation of symptoms in both chronic and acute conditions. SUMMARY: The present study demonstrated the effectiveness of a natural substance Lignisul MSM on acute athletic injuries, such as muscle sprains and strains, with a negligible level of toxicity and, of even greater importance, a significant reduction in visits necessary to the doctor's office or treatment facility.
BIBLIOGRAPHY 1. Jacob, S. W., E .E. Rosenbaum, and D. C. Wood. Dimethyl Sulfate (Basic Concepts), New York; Marcel Dekker, Inc. 1971. 2. Jacob, S. W., ed. Biological Actions of Dimethyl Sulfoxide, Volume 243. New York New York Academy of Sciences, 1975. 3. Jacob, S. W., R. J. Herschler, and H. Schmellenkamp. The Use of DMSO in Medicine, Munich: Springer Verlag, 1985. 4. Jacob, S.W., and J. G. Kappel. DMSO, Munich: Springer Verlag, 1988. 5. Tarshis, Barry. DMSO — The True Story of a Remarkable Pain-Killing Drug. New York: Morrow, 1981. 6. Lawrence, R.M. "Methylsulfonylmethane (MSM): A double-blind study of its use in Degenerative arthritis." International Journal of Anti-Aging Medicine, Summer 1998, I (I);50. 7. Moore, R.D., and J. I. Morton. "Dimished inflammatory joint disease in MRL/1pr mice ingesting dimethyl sulfoxide (DMSO) or methylsulfonylmethane (MSM)." Federation of American Societies for Experimental Biology, 69th annual meeting. April 1985, p.692 8. Morton, Jane I., and R. D. Moore. "Lupus nephritis and deaths are dimished in B/W mice drinking 3% water solutions of dimethyl sulfoxide (DMSO) and dimethyl sulfone (DMSO (2). "Journal of Leukocyte Biology, 1986, 40 (3);322. 9. Morton, Jane I. And Benjamin V. Siegel. "Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease." Proceedings of the Society for Experimental Biology and Medicine, 1986, 183:227-30. 10. Moss, Jeffrey. "A perspective on sulfur — Is it the most ignored, misunderstood essential trace element." The Moss Nutrition Report, August 1997, Hadley, M.A. 11. Osterberg, E. E., et al. "Absorption of sulfur components during treatment by sulfur baths." Archives Dermatol. Syphitol, 1929, 20:156-66 12. Jacob, Stanley, and Robert Herschler. :Pharmacology of DMSO: Crybiology, 1986.
LIGNISUL MSM (Methylsulfonylmethane)
A DOUBLE BLIND STUDY OF ITS USE IN DEGENERATIVE ARTHRITIS (A Preliminary
By Ronald M. Lawrence, M.D., Ph.D. Assistant Clinical Professor U.C.L.A. School of Medicine Los Angeles, California
Methyl-Sulfonyl-Methane (M.S.M.) is an organic sulfur compound which is a metabolite of dimethyl-sulfoxide (D.M.S.O.). It is a white, odorless, slightly bitter tasting, crystalline substance, which contains 34 percent elemental sulfur. It is easily soluble in water. Its chemical formula is (CH3)2SO2. It has been suggested by Lovelock and his associate's (1) that M.S.M. and its related compounds D.M.S.O. and D.M.S. (dimethyl sulfide) provide 85 percent of the sulfur found in all living organisms. The cycle of these naturally occurring sulfur compounds begins in the ocean where microscopic plankton release sulfur compounds called dimethyl sulfonium salts. These salts are transformed in the ocean into the very volatile compound D.M.S. which escapes from the water as a gas which rises into the upper atmosphere. Exposed to ozone and high energy ultraviolet light the D.M.S. is converted to D.M.S.O. and M.S.M. Both the D.M.S.O. and M.S.M. are very soluble in water and they return to the surface of the earth in rainwater. Plants then take up the two compounds into their root systems concentrating them up to one hundred fold. M.S.M. (sulfur) is incorporated into the plant structure. Through the process of plant metabolism the M.S.M., along with the other sulfur compounds it has spawned, are ultimately mineralized and transported back to the ocean and the sulfur cycle begins again. M.S.M. is found naturally in the human body. It occurs in the blood and in other organs and has been detected in normal human urine (2). The level of M.S.M. in the circulatory system of an adult human male is about 0.2 parts per million (3). Normal human adults excrete from four to eleven milligrams M.S.M. per day in their urine. Experiments using radiolabled sulfur (S35) in M.S.M. have shown that after ingestion the sulfur in M.S.M. helps form the essential amino acids methionine and cysteine (4). M.S.M. is rated as one of the least toxic substances in biology, similar in toxicity to water (5). The lethal dose (LD50) of M.S.M. for mice is over 20 grams per kilogram of body weight. Hundreds of patients have been treated at the Oregon Health Sciences University (6) with oral M.S.M. at levels above two grams daily for many years without serious toxicity. Since sulfur is found to be needed for the formation of connective tissue, M.S.M. has been studied for its use in treating arthritis of various types (7). Sulfur concentration in arthritic cartilage has been shown to be about one-third the level compared to normal cartilage (8). In addition, the amino acid cystine has been noted to be diminished in arthritic patients. Personal communication with Stanley Jacob, M.D., Gerlinger Professor, Department of Surgery, Oregon Health Sciences University, Portland, Oregon, substantiated his personal experiences using M.S.M. in the treatment of patients with degenerative (osteoarthritis) arthritis. Study Design M.S.M. was provided in a crystalline form (LIGINSULMSM™) which we encapsulated in a clear gelatin capsule providing 750 mgms of LIGINSULMSM™) per capsule. The placebo substance, which was also placed in clear gelatin capsules, consisted of sugar (sucrose) to which a small amount of quinine sulfate was added to create a slightly bitter taste. This was done in case the capsule was opened and tasted, since M.S.M. also has a slightly bitter taste. A total of sixteen patients were studied over a period of four months. Initially twelve patients were admitted to the study and subsequently (two months later) an additional four patients were added to the study group. The initial twelve patients were divided as follows. Eight were given the M.S.M., while four received the placebo. Later, the additional four patients were divided into two on M.S.M. and two on placebo. Totally, therefore, we had ten patients on M.S.M. and six patients on placebo. Criteria for Selection Patients ranged from age 55 to age 78. All patients had x-ray evidence of degenerative joint disease (degenerative arthritis). All patients had pain in the involved area ranging from four weeks to six months. Most of the patients had tried non-steroidal anti-inflammatory drugs or aspirin type compounds. None had taken steroids either orally or by injection. All non-steroidal anti-inflammatory drugs or other anti-arthritic medications or alternative health remedies were stopped a least three days prior to their entering the study. Patients were randomly chosen by lot and assigned to either the active (M.S.M.) group or the placebo group. The treating physician did not have knowledge as to which patient received which agent until after the completion of the study. Records were kept by an independent evaluator until the study was terminated. Both the patients and the physicians were blinded. Of the eight patients on Liginsul M.S.M., two had osteoarthritis in their hands, three had lumbar degenerative joint disease, two had degenerative arthritis in their knees, and one had arthritis in the shoulder. Of the six patients who received the placebo, two had degenerative arthritis in the knees, two had lumbar degenerative joint disease, one had degenerative arthritis in the hip, and one had osteoarthritis in the neck. Dosage Patients were instructed to take two capsules on an empty stomach in the A.M. after arising and one capsule before lunch. This constituted a 2250 milligram dose of Liginsul M.S.M. daily and zero dose of M.S.M. on the placebo. Measurement Each patient was administered a visual analog scale (V.A.S.) which consisted of a 10-cm line anchored at one end by a label of "no pain" and at the other end a label of "pain as bad as could possibly be." The scoring is accomplished by having the patient mark the line indicating pain intensity, and the line is then measured to the mark on a 1-100 scale (9). Results The V.A.S. was completed by each patient at the four week and at the six week visit. Records were measured by an independent evaluator. At the four week visit, the patients on the Liginsul M.S.M. showed a 60 percent improvement on average, while at the six week V.A.S. evaluation the patients showed and 82 percent improvement in pain on average. Those on the placebo showed an improvement of 20 percent on average at four weeks and an 18 percent improvement on average at six weeks. ABSTRACT This preliminary simple study was performed to initially evaluate 16 patients suffering from degenerative arthritis as to the effect of using Liginsul M.S.M. to control their pain. Eight patients, randomly chosen, were treated with 2250 mgms of M.S.M. per day. Six patients received placebo capsules. Results indicate a better than 80 percent control of pain within six weeks of beginning the study, while only two patients showed a minimal improvement (less than 20 percent) on the placebo. Although this was only a simple preliminary study, it appears that a more intensive investigation of M.S.M. is warranted. A larger group of arthritic patients an additional measurement evaluation (such as range of motion, etc.) should be utilized in such a future study. Liginsul M.S.M. may offer a significant new nutritional substance for the control of arthritic pain as a safe, non-toxic method. REFERENCES 1.Lovelock, J.E. et al. Nature, Vol. 237, p452, 1972 2.Williams, K.I.H. et al. Arch Biochem Biophys, Vol. 113, p251, 1966 3.Jacob, S.W. and Herschler, R., Ann NY Acad Sci, Vol. 411, pxii 1983 4.Richmond, V.L., J Nutrition, Vol. 116 NO. 6, June, 1986 5.Deichman, W.B. & Gerarde, H.W. "Toxicology of Drugs & Chemicals, 4th Edition, Arcadia Press, 1969 6.Jacob, S.W., Oregon Health Sciences University, Portland, Oregon, Personal communication 7.Jacob, S.W., Oregon Health Sciences University, Portland, Oregon, personal communication 8.Rizzo, R. et al. Jour Exp Zool, 1995 September, 1,273(1):82-6 9.Carlson
Mother Nature made our bodies so that they can make new cells every day of our lives. It is very important that our glands put out the right enzymes and hormones to regulate and keep our bodies healthy. Without the proper amount of sulfur or MSM in our system, we cannot produce good, healthy cells. We can get this essential nutritional sulfur from some of our foods: milk, fruits, vegetables, meat and fish have minute amounts of MSM. Supplementation is the best way to get MSM into our diets. MSM ~ Methylsulfonylmethane Sick of being sick?.... Tired of being.....Tired? Want to feel good again? Read on! Most people have heard of DMSO, and how hundreds of thousands of people have been helped by using DMSO. A few years ago, the world's leading DMSO researcher, the eminent Dr. Stanley Jacob of the Oregon Health Sciences University, discovered and was able to isolate an extremely important and beneficial part of DMSO. It is referred to as Methyl Sulfonyl Methane, and is simply known as MSM. It was determined that it was the MSM part of DMSO that brings so many health benefits to those that suffer from various ailments and diseases. MSM provides the health-giving benefits without any nuisance side effects. It is estimated that the human body uses up at least 1/8 teaspoon of MSM each day! MSM is a natural form or organic sulfur found in all living organisms, and is present in low concentrations in our body fluids and tissues. It is found in a variety of fresh foods, including fruit, vegetables, meat, fish, and milk. MSM helps our bodies utilize the vitamins that we take, providing the means to derive the maximum benefit from those vitamins. MSM is part of the Amino Acid Chain. Without the proper amount of MSM in our bodies, the amino acids will continue to build the glands, but fail to produce the correct enzymes, making us prone to unnecessary illness. MSM is the flexible bond between proteins. When a cell dies, a new cell takes its place. Without the needed amount of MSM, it attaches but becomes rigid. When tissues lose their flexibility, problems develop with the lungs and other parts of the body. MSM detoxifies the body and increases blood circulation. Because there are few nerves in the bones, our pain comes from the soft tissue. Aspirin shuts off the nerves, but the muscles are still damaged. MSM takes out the inflammation, permits the muscles to heal and prevents them from becoming sore. If you play sports or work-out in a gym and normally get sore muscles the next day, take 1/2 teaspoon (or 3 capsules) of MSM before exercise and you will notice a difference. If taken after exercise, the soreness will go away faster. MSM also prevents overreaction to other medicines, so it does not work against any medications. MSM controls acidity in the stomach, so it can help ulcers. MSM coats the intestinal tract so parasites lose their ability to hang on. They are then flushed away. This could prevent colon problems. MSM is no more toxic than water. It can never hurt anyone. If you overdose, the extra MSM becomes inert and just passes through your system. MSM has one side effect...your fingernails and hair will grow faster and become stronger. This is because there is more MSM in hair and nail cells than in any other part of the body.
SOME FACTS ABOUT ORGANIC SULFUR
Sulfur is a mineral found in rather high concentrations in our body tissues. About half of the body's total sulfur is concentrated in the muscles, while the other half is found in the brain, hair, skin and bones. Sulfur comprises 0.25 percent of our body weight. Sulfur has a vital relationship with protein, since sulfur is found in the amino acids methionine, cystine, and cysteine. Thus, these amino acids are known as the sulfur bearing amino acids which are considered the building blocks of protein. The sulfur-bearing amino acid methionine is absolutely essential to health! This means is must be supplied by live food, or the food supplement MSM. A lack of proper protein in our diet, therefore means a lack of the vital organic sulfur necessary for good health. Proteins contain sulfur, while carbohydrates and fats do not. Sulfur is necessary for collagen synthesis. Collagen is an insoluble fibrous protein found in vertebrates. It is the dominant component of connective tissue fibrils and bones. Sulfur operates as a synthesizer and activator with the B vitamins, thiamin, Vitamin C, biotin, and pantothenic acid, all of which are needed for metabolism and healthy nerves. Sulfur plays an important part in tissue breathing, the process whereby oxygen and other substances are used to build cells and release energy. Sulfur also helps to maintain overall body balance between acidity and alkalinity, and works importantly with the liver to excrete bile. Research indicates that perhaps sulfur's most important health role is in carbohydrate metabolism, which is significant for hypoglycemics and diabetics. Sulfur is a significant component of insulin, the protein hormone secreted by the pancreas that is essential to the metabolism of carbohydrates. A lack of nutritional sulfur in the diet can result in low insulin production. On the other hand, a diet that contains adequate amounts of sulfur might increase the body's ability to produce insulin to the point where insulin injections can be reduced. Because nutritional sulfur helps keep skin, hair and nails healthy, it has been referred to as "Nature's Beauty Mineral." Welcome to the "Get Well / Stay Well" world of the nutritional sulfur MSM ~ 99.9% Pure!
MSM: DMSO After 20 years
Stanley W. Jacob and Robert Herschler Department of Surgery Oregon Health Science University Portland, Oregon.
MSM, an odorless essentially tasteless, white crystalline chemical demonstrates usefulness as a dietary supplement in men and lower animals. Our research suggests that a minimum concentration in the body may be critical to both normal function and structure. Limited studies suggest that the systemic concentration of MSM drops in mammals with increasing age. This may be due to dietary habits where one ingests foods with lower MSM potential with maturity or possibly there is a change in the renal threshold. Healthy juvenile rabbits maintain a level at or above 1 PPM body weight, with milk being the dominant food and source. Cow's milk normally contains between 2 and 6 ppmMSM, dependent on source and freshness. In an adult man, the circulating concentration varies but may average about 0.2 - 0.25 ppm. We have no estimate of total body concentration as yet, but suspect that MSM is banked in some of the organs, other than the adrenals. Based on radiolabel (35 S) studies, the residence time of a single challenge in mammals may be several weeks with gradual dumping via the renal system. Daily output of urine contains several milligrams of MSM. This possibly is not the dominant excretory route. The following abnormal conditions seen in the clinic have responded to oral MSM generally administered at dosage levels of 250-270 mg/day. Response to allergy: Oral MSM moderates diverse allergic responses as to pollen and foods. Antiallergy medication and dissemination methods may be sharply reduced. Control of hyperacidity: Subjects that are chronic users of various antacids and histamine H 2 receptor antagonists prefer MSM by reason of relief obtained coupled with freedom from serious, untoward effects. Hypersensitivity to drugs: Subjects demonstrating drug hypersensitivity to aspirin, several nonsterioid antiarthritic agents (Naprosy, Indocin, Motria), and oral antibiotics, were drug tolerant when MSM was given within an hour before or concurrent with the sensitizing drug. Control of constipation: Particularly in the older population seen in our clinic, chronic constipation can be a medical problem of concern. To date, over 50 subjects presenting chronic constipation have gained prompt and continuing relief by supplementing the diet with 100 to 500 mg of MSM per day. We have seen some individuals with severely restricted lung function. Of these, only a few cooperated in vital function assessments. All cooperated in endurance measurements. Limited objective and strong subjective evidence suggests that MSM is a useful dietary supplement to reduce lung dysfunction. Anti-parasitic action: In vitro and in vivo tests suggest MSM has an activity against a variety of medically important parasitic tracts, MSM, for example, is active against Giardia, Trichomondads, and round worms. MSM may affect such infections by competing for binding or receptor sites at the mucous membrane surface, presenting a blocking interface between host and parasite. We are at present evaluating the action of MSM with a variety of abnormal or medical problems to determine whether any are responsive to a diet supplemented by MSM. We are intrigued by the fact that MSM is a contestant factor in all normal diets of vertebrates and somewhat mystified by the seeming need of the body of adults for a concentration level above that available from a diet presumed as normal. We hope soon to have data defining any specific interacting role that MSM may have with the water-soluble vitamins, particularly Vitamin C, which like MSM is reportedly banked in the adrenals. It is not possible to directly compare DMSO and derivative MSM, though of the same chemical family. Each is unique unto itself. MSM is a dietary factor derivable from most natural food. It is conveniently taken alone or in foods. Taken by mouth, there is no after-breath. DMSO has certain unpleasant attributes not possessed by MSM. While MSM is a dietary factor, DMSO is not. DMSO readily penetrates the dermas and less complicated membrane systems while MSM does not. Each contribution to the well-being of mankind, but in differing ways. Both have important implications. --as reported in the Journal of the New York Academy of Sciences.
Jack O. Hyle Ph.D., P.M.D., P.C.
MSM I. The Patients - 170 volunteers A. Arthritis 1. Rheumatoid - 120 2. Osteo -------- 28 B. Burstitis ------------ 15 C. Allergy ------------- 4 D. Emphysema ---------1 E. Dogs -------------------2 II. Administered Each patient was given five (5) teaspoons laboratory grade MSM. Instructions: Dissolve one (1) level teaspoon of MSM in a small glass of water, drink quickly. If results occur within 30 hours, do not take again until needed. If no results within 30 hours, take as above every other day. III. The Results A. 129/170 - mild-to-dramatic pain relief B. 41/170 - no change IV.
Discussion A. MSM alone is excellent for pain relief. B. The patients that MSM "did not work," seemed to have a blocking effect from standard arthritic drugs.